Pilose antler peptide promotes osteoblast proliferation, differentiationand mineralization via the insulin signaling pathway
作者: Changjun YunWenjie QianJunyi WuChenxi YuanSongzhou JiangJinpeng Lv
作者单位: 1Department of Orthopedics, Wujin Hospital Affiliated with JiangsuUniversity, Changzhou, Jiangsu 213000, P.R. China
2College of Pharmaceutical Engineering and Life Sciences, ChangzhouUniversity, Changzhou, Jiangsu 213000, P.R. China
刊名: Experimental and Therapeutic Medicine, 2020, Vol.19 (2), pp.923-930
来源数据库: Spandidos Journal
DOI: 10.3892/etm.2019.8286
原始语种摘要: Osteoporosis is a severe bone disease characterized by a decrease in thedensity and structure of bones, with high risks of fractures. Pilose antler peptide(PAP), extracted and purified from deer antlers, can promote regeneration andfracture healing, and strengthen sinews and bone. To determine whether PAP canpromote osteoblast development and to elucidate the molecular mechanisms underlyingits functions, the present study investigated the effects of PAP on osteoblastproliferation, differentiation and mineralization, and the role of the insulinsignaling pathway using MTT assay, alkaline phosphatase activity assay, westernblot analysis and reverse transcription‑quantitative PCR. The present resultssuggested that PAP promoted osteoblast proliferation, differentiation and mineralizationin...
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关键词翻译
关键词翻译
  • osteoblast 成骨细胞
  • pathway 轨道
  • insulin 胰岛素
  • antler 鹿角
  • signaling 发信号
  • peptide 
  • proliferation 增生
  • PAP PORT-AU-PRINCE
  • phosphatase 磷酸酶
  • present 出席的