Potential mechanism of ferroptosis in pancreatic cancer (Review)
作者: Gang ChenGuangqi GuoXiaodong ZhouHongxia Chen
作者单位: 1Department of Gastroenterology, The First Affiliated Hospitalof Nanchang University, Nanchang, Jiangxi 330006, P.R. China
2Department of Obstetrics and Gynecology, The First AffiliatedHospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
刊名: Oncology Letters, 2020, Vol.19 (1), pp.579-587
来源数据库: Spandidos Journal
DOI: 10.3892/ol.2019.11159
原始语种摘要: Despite the incidence rates of pancreatic cancer being low worldwide, themortality rates remain high. To date, there is no effective drug treatment forpancreatic cancer. Numerous signalling pathways and cytokines regulate the occurrenceand development of pancreatic cancer. Ferroptosis is a non‑traditional form ofcell death resulting from iron‑dependent lipid peroxide accumulation. Studieshave demonstrated that ferroptosis is associated with a variety of different typesof cancer, such as breast cancer, hepatocellular carcinoma and pancreatic cancer.The present study demonstrated that ferroptosis controls the growth and proliferationof pancreatic cancer, providing a new approach for the treatment of pancreaticcancer. Iron metabolism and reactive oxygen species metabolism are the key...
全文获取路径: Spandidos 
影响因子:0.237 (2012)

  • pancreatic 胰的
  • cancer 癌症
  • hepatocellular 肝细胞性的
  • worldwide 世界的
  • demonstrated 探明的储量
  • associated 相关的
  • digestive 消化道
  • carcinoma 癌症
  • breast 胸部
  • metabolism 代谢