Knockdown of ST7-AS1 inhibits migration, invasion, cell cycle progressionand induces apoptosis of gastric cancer
作者: Shuang CaiYang WengPengliang LiuFeng Miao
作者单位: 1The Fourth Affiliated Hospital of China Medical University, Shenyang,Liaoning 110032, P.R. China
刊名: Oncology Letters, 2020, Vol.19 (1), pp.777-782
来源数据库: Spandidos Journal
DOI: 10.3892/ol.2019.11145
原始语种摘要: Role of ST7‑AS1 in the malignant progression of gastric cancer (GC) andits molecular mechanisms were investigated. ST7‑AS1 level in GC tissues and matchednormal tissues was determined by quantitative real‑time polymerase chain reaction (qRT‑PCR).Its level in GC patients presenting different tumor stages and tumor sizes wasdetermined. Subsequently, ST7‑AS1 level in epithelial cells of gastric mucosaand GC cell lines was examined. Cellular behavior of GC cells, including viability,apoptosis, migration, invasion and cell cycle, influenced by ST7‑AS1 was evaluated.The interaction between ST7‑AS1 and EZH2 was assessed by RNA immunoprecipitation (RIP)assay. The involvement of EZH2 in the progression of GC mediated by ST7‑AS1 wasidentified. ST7‑AS1 was upregulated in GC tissues and cell lines....
全文获取路径: Spandidos 
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影响因子:0.237 (2012)

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关键词翻译
关键词翻译
  • invasion 侵入
  • gastric 胃的
  • apoptosis 细胞死
  • migration 迁移
  • cycle 旋回
  • cancer 癌症
  • attenuated 减毒的
  • cells 麻风细胞
  • invasive 侵入的
  • correlated 相关