Antitumor activity of Endostar combined with radiation against humannasopharyngeal carcinoma in mouse xenograft models
作者: Juying ZhouLili WangXiaoting XuYu TuSongbing QinYuzhen Yin
作者单位: 1Department of Radiation Oncology, The First Affiliated Hospitalof Suzhou University, Suzhou, Jiangsu, P.R. China
2School of Radiation Medicine and Public Health, Medical Collegeof Soochow University, Suzhou, Jiangsu, P.R. China
刊名: Oncology Letters, 2012, Vol.4 (5), pp.976-980
来源数据库: Spandidos Journal
DOI: 10.3892/ol.2012.856
原始语种摘要: Radiation treatment for nasopharyngeal carcinoma (NPC) is common and effective.However, local recurrence occurs frequently. Endostar, a novel recombinant humanendostatin, is an antiangiogenic drug with a potent antitumor effect. The presentstudy aimed to observe and explore the radiosensitization effects of Endostaron NPC and its underlying mechanism. The NPC subcutaneous transplantation tumoranimal model was established to evaluate the antitumor activity of Endostar combinedwith radiation (Endostar + radiation) treatment compared with monotherapy (Endostaror radiation). Tumor growth and tumor weight were measured to evaluate the antitumoreffect. The level of vascular endothelial growth factor (VEGF) and microvesseldensity (MVD) were measured using immunohistochemical staining of the...
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影响因子:0.237 (2012)

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关键词翻译
关键词翻译
  • radiation 辐射
  • carcinoma 癌症
  • combined 组合
  • antitumor 抗癌的
  • xenograft 异种移植片
  • against 反对
  • activity 活度
  • potent 强大的
  • subcutaneous 皮下的
  • recurrence 循环