Profiling of transcripts and proteins modulated by the E7 oncogene inthe lung tissue of E7-Tg mice by the omics approach
作者: Eunjin KimJeongwoo KangMinchul ChoSojung LeeEunhee SeoHeesook ChoiYumi KimJunghee KimKum KangKwang KimJaeyong HanYhunyhong SheenYoung YumSue-Nie ParkDo-Young Yoon
作者单位: 1Department of Bioscience and Biotechnology, Konkuk University,Seoul 143-701, Korea
刊名: Molecular Medicine Reports, 2009, Vol.2 (1), pp.129-137
来源数据库: Spandidos Journal
DOI: 10.3892/mmr_00000073
原始语种摘要: The E6 and E7 oncoproteins of human papilloma virus (HPV) type 16 havebeen known to cooperatively induce the immortalization and transformation of primarykeratinocytes. We established an E7 transgenic mouse model to screen HPV-relatedbiomakers using the omics approach. The methods used to identify HPV-modulatedfactors were genomics analysis by microarray using the Affymetrix 430 2.0 arrayto screen E7-modulated genes, and proteomics analysis using nano-LC-ESI-MS/MSto screen E7-modulated proteins with the lung tissue of E7 transgenic mice. Accordingto omics data, cyclin B1, cyclin E2, topoisomerase IIα, calnexin, activated leukocytecell adhesion molecule CD166, actinin α1, diaphorase 1, gelsolin, platelet glycoprotein,and annexin A2 and A4 were up-regulated in the E7-Tg mice, while...
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关键词翻译
关键词翻译
  • proteins 蛋白质
  • troponin 肌钙蛋白
  • tissue 组织
  • modulated 巳的
  • expression 表示
  • transformation 变换
  • actinin 辅肌动蛋白
  • cyclin 细胞周期蛋白
  • together 共同
  • confirmed 已确认的