Expression of the immune checkpoint receptor TIGIT in seminoma
作者: Andrea HinschNiclas BlessinRonald SimonMartina KluthKristine FischerClaudia Hube‑MaggWenchao LiGeorgia Makrypidi‑FrauneBjörn WellgeTim MandelkowNicolaus DebatinDoris HöflmayerMaximilian LennartzGuido SauterJakob IzbickiSarah MinnerFranziska BüscheckRia UhligDavid DumTill KrechAndreas LuebkeCorinna WittmerFrank JacobsenEike BurandtStefan SteurerWaldemar Wilczak
作者单位: 1Department of Pathology, University Medical Center Hamburg‑Eppendorf,D‑20246 Hamburg, Germany
2ONCOdianova GmbH, D‑20354 Hamburg, Germany
3Department of General, Visceral and Thoracic Surgery, UniversityMedical Center Hamburg‑Eppendorf, D‑20246 Hamburg, Germany
刊名: Oncology Letters, 2019, Vol.18 (2), pp.1497-1502
来源数据库: Spandidos Journal
DOI: 10.3892/ol.2019.10428
原始语种摘要: A characteristic feature of testicular seminoma is the abundance of immunecells in the tumor microenvironment, raising the possibility that immune checkpointinhibitors may serve as a therapeutic option in these types of tumors. T cellimmunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory immune checkpointreceptor in analogy to PD‑1, and drugs targeting TIGIT are currently being investigatedin clinical trials. Little is known about the expression of these proteins intesticular seminomas. Therefore the present study performed immunohistochemicalanalysis to determine the relative abundance of TIGIT and PD‑1 in relation tothe total CD3+ immune cell infiltration in a tissue microarray (TMA) constructedfrom 78 seminoma patients. The fraction of TIGIT+ and PD‑1+ lymphocytes was...
全文获取路径: Spandidos 
影响因子:0.237 (2012)

  • immune 免疫的
  • seminoma 精原细胞瘤
  • checkpoint 检查地点
  • available 可供应的
  • relative 相对的
  • expression 表示
  • expressed 榨出的
  • targeting 导向目标
  • predominance 优势
  • raising 提高