"Simultaneous Estimation of Ribociclib and Palbociclib in Bulk Samples by Reverse Phase High Performance Liquid Chromatography
作者: Sreelakshmi M* R L C Sasidhar Raviteja B
刊名: Inventi Impact - Pharm Analysis & Quality Assurance, 2019, Vol.2019
来源数据库: Inventi
原始语种摘要: This work concerns with the development and validation of a simple, specific and cost effective RP-HPLC method for simultaneous estimation of ribociclib and palbociclib in bulk samples. Chromatography was carried on Kromasil C18 column with mobile phase comprising of 20 mM phosphate buffer (pH-5): methanol: acetonitrile (40:30:30, v/v/v). The flow rate was adjusted to 1 ml/min with PDA detection at 260 nm. The retention times of ribociclib and palbociclib were found to be 3.47min and 4.48 min, respectively and other replicate standard system suitability parameters are within the limit and uniform. The different analytical parameters such as accuracy, precision, linearity, robustness, limit of detection (LOD), limit of quantification (LOQ) were determined according to the International...
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  • simultaneous 同时的
  • respectively 分别
  • effective 有效的
  • standard 标准
  • range 射程
  • acetonitrile 乙腈
  • retention 保留
  • phosphate 磷酸盐
  • analytical 分析的
  • robustness 坚固性