"Protective Effect of Human Umbilical Cord Blood Cell on Cardiomyopathy in Male Wistar Rats
作者: Rupali A Patil* Prashant V Vyavahare Chaitali M Diwane
刊名: Inventi Impact - Molecular Pharmacology, 2019, Vol.2019
来源数据库: Inventi
原始语种摘要: This study examined the cardioprotective activity of human umbilical cord blood cells (hUCBC) in doxorubicin (Dxr) induced cardiomyopathy in Wistar rats. Wistar rats treated with doxorubicin (50 mg/kg i.p.) revealed cardiac damage that was manifested by the elevation of serum marker enzymes such as lactate dehydrogenase (LDH), aspartate aminotransaminase (AST) and alanine aminotransaminase (ALT). The animals showed significant changes in the biochemical parameter such as in-vivo antioxidant enzyme levels (superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase) and lipid peroxidation levels, lipid profile and histopathological examination. Pretreatment with hUCBC significantly reversed elevation in serum marker enzymes and restored the enzyme activity and...
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关键词翻译
关键词翻译
  • enzymes 酶类
  • induced 感应的
  • reversed 倒转的
  • lipid 脂质
  • cardiomyopathy 心肌病
  • superoxide 过氧化物
  • doxorubicin 阿霉素
  • elevation 隆起
  • peroxidation 过氧化
  • umbilical 供应脐带