"Optimization and Development of Fast Disintegrating Liquisolid Compact of Sertraline Hydrochloride for Dissolution Enhancement Using Factorial Design
作者: Makarand Suresh Gambhire Apurva Vinodkumar Jadhav*
刊名: Inventi Impact - Pharmaceutical Process Development, 2019, Vol.2019
来源数据库: Inventi
原始语种摘要: The objective of this study was to optimize and develop fast disintegrating liquisolid compact of sertraline hydrochloride to enhance the dissolution and study the dissolution in different pH conditions. Fast disintegrating liquisolid compacts were prepared from Neusilin US2 as a carrier material, Aeroperl 300 as a coating material, crospovidone as a superdisintegrants and Tween80 as a non-volatile liquid vehicle. In liquisolid formulations the ratio of carrier to coating material was kept enhancing. The ratio 40 gives optimal results relative to other ratios. The pre-compression evaluation includes: flow properties, angle of slide and FT-IR study for drug-excipient compatibility. The post-compression evaluation which includes: friability, hardness, wetting time, in-vitro disintegration...
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  • disintegration 蜕变
  • ratio 
  • solubilization 加溶
  • material 充填料
  • dissolution 溶解
  • volatile 挥发性的
  • enhanced 增强
  • evaluation 评价
  • compression 压缩
  • release 释放