Studying of lipophilicity of potential biological active cyanoacetamide derivatives
作者: Suzana ApostolovĐenđi Vaštag
作者单位: 1University of Novi Sad, Faculty of Science, Department of Chemistry, Biochemistry and Environmental Protection, Novi Sad, 21000, Serbia.
刊名: Journal of Engineering & Processing Management, 2017, Vol.9 (1), pp.1-9
来源数据库: Faculty of Technology Zvornik, university of east Sarajevo
DOI: 10.7251/JEPM1709001A
关键词: CyanoacetamidesLipophilicityPharmacokinetic parametersRPTLCToxicity
原始语种摘要: By applying the Lipinski’s rule for selected cyanoacetamide derivatives the possible existence of biological activity is theoretically investigated. Alos,using appropriate software packages and applying reverse-phase thin-layer chromatography (RP TLC18 F254s) in water-t-butanol, water-dimethylformamide and water-dimethylsulfoxide the lipophilicity of the studied cyanoacetamides was determined. Chromatographic retention parameters, RM0 and m, as presumed criteria of lipophilicity of examined cyanoacetamides were correlated by linear regression analysis with standard measure of lipophilicity, log P, with important pharmacokinetic predictors and selected parameters of toxicity. The established linear dependences are described by high regression coefficient values, r, which showed that RP...
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  • lipophilicity 亲油性
  • potential 
  • cyanoacetamide 氰基乙酰胺
  • presumed 假定
  • determination 测定
  • derivatives 派生物
  • parameters 参数
  • biological 生物学的
  • applying 施加
  • toxicity 毒性