Objective: To examine the effects of passive music therapy on anxiety and vital signs of first-time, peripheral-insertion central catheter lung cancer patients. (#br)Methods: A controlled randomized clinical trial was conducted. Three hundred and four lung cancer patients meeting the inclusion and exclusion criteria were recruited and randomly assigned to either a test group or a control group. The control group received standard care only. The test group received standard care and passive music therapy while undergoing catheterization, with the interference time during hospitalization and for 24 h post-catheterization. (#br)Results: A variance analysis of repeated measurements showed differences in anxiety scores post-intervention (F = 68.55, p < 0.001), time (F = 938.86, p < 0.001), and... time and intervention interactions (F = 204.56, p < 0.001) between the test group and control group before, during, and after catheterization was statistically significant. A comparison of diastolic blood pressures and heart rates before and after catheterization between the two groups showed a significant statistical difference (p < 0.05). A comparison of systolic blood pressures and respiration between the two groups was not statistically significant. Conclusions: Passive music therapy during PICC placement can reduce anxiety lung cancer patient anxiety, lower patient diastolic blood pressure, and slow heart rate resulting in better experience patients and having it clinical application significance.