Objective: To explore the relationships between prenatal risk factors and tic disorders (TDs), and provide an evidence-based medical evidence for the prevention of TDs. (#br)Methods: In the 1:1 matched case control study, 150 children with TDs from West China Second Hospital and 150 healthy children were enrolled, and they were investigated used a questionnaire. The related prenatal risk factors resulting in TDs were analyzed using univariate and multivariate logistic regression. (#br)Results: In the case group, there were 110 male patients among 150 newly diagnosed patients with TDs, aged 9.18 ± 2.60 years old. In the control group, there were 109 healthy controls among 150 healthy children, aged 9.09 ± 2.52 year old. Univariate logistic regression showed that pregnant age, pregnancy... reaction, childbirth complications, perinatal asphyxia, passive smoking, mental stimulation during pregnancy and gestational age were the risk factors for TDs (p < 0.05). Multivariate logistic regression model analysis showed that pregnant age, childbirth complications, passive smoking, and mental stimulation during pregnancy were the risk factors for TDs. (#br)Conclusion: Pregnant age, childbirth complications, passive smoking, mental stimulation during pregnancy and other risk factors may be associated with TDs. Health education for the disease should be strengthened and the avoidance of prenatal risk factors should be actively advocated to prevent TDs.