Objective: To investigate the efficacy and mechanism of electroacupuncture treatment in rats of sciatic nerve injury. (#br)Methods: Seventy five male SD rats were randomly divided into control group, model group and electro-acupuncture (EA) group. In the EA group, “Zusanli” points and “Yanglingquan” points of the left lower extremity were selected. The frequency of EA was 5 Hz, and EA performed for 15 minutes a day. The sciatic nerves were collected at 1 week, 2 weeks, 3 weeks, 4 weeks and 6 weeks, respectively, and the expression of SOCS1 protein was detected by Western blot. (#br)Results: The results of gait analysis showed that the electro-acupuncture group tended to be more in the control group than in the model group. The wet weight of triceps surae in rats was closer to 1 than that... in EA group and model group. Nissl staining showed that the number of Nissl bodies in EA group was significantly higher than that in model group. The expression of SOCS1 protein in the model group was significantly higher than that in the EA group and the control group. (#br)Conclusion: EA may repair peripheral nerve injury by inhibiting the expression of SOCS1 in sciatic nerve.