Correlation of programmed death-ligand 1 expression with gene expression and clinicopathological parameters in Indian patients with non-small cell lung cancer
作者: Manish KumarBhupesh GuleriaShivashankar SwamySneha Soni
作者单位: 1Department of Medical Oncology, Army Hospital Research and Referral, New Delhi
2Assistant Professor, Community Medicine, Rama Medical College, Hapur, Uttar Pradesh
刊名: Lung India, 2020, Vol.37 (2), pp.145-150
来源数据库: Wolters Kluwer Journal
DOI: 10.4103/lungindia.lungindia_488_19
关键词: Anaplastic lymphoma kinaseClinicopathologicalEpidermal growth factor receptorNon-small cell lung cancerProgrammed cell death-ligand 1
原始语种摘要: Objectives: The aim of this study is to evaluate the incidence of programmed cell death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) cases and its correlation with gene mutation and clinicopathological parameters. Methods: Samples from NSCLCs patients were studied for PD-L1 expression through immunohistochemistry (IHC) using Rabbit anti-human PDL-1/CD274 Monoclonal Antibody. Genetic mutations were studied using IHC/fluorescence in situ hybridization (FISH) methods (for anaplastic lymphoma kinase [ALK]) or polymerase chain reaction/gene sequencing analysis (for epidermal growth factor receptor [EGFR]). Pearson's correlation coefficient (r) was used for correlation analysis. PD-L1 expression was analyzed for association with clinicopathological features. Results: Of the...
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  • expression 表示
  • small 小的
  • parameters 参数
  • programmed 制订计划了的编制程序了的按程序工作的
  • observed 观察到的
  • sequencing 排序
  • demonstrated 探明的储量
  • lymphoma 淋巴瘤
  • ligand 配合体
  • evaluate 求...的值