Evaluation of Bismuth Oxide Nanoparticles as Radiosensitizer for Megavoltage Radiotherapy
作者: Noor Nabilah Talik SisinSafri Zainal AbidinYunus Muhammad AmirM. Zin HafizKhairunisak Abdul RazakWan Nordiana Rahman
刊名: International Journal on Advanced Science, Engineering and Information Technology, 2019, Vol.9 (4), pp.1434-1443
来源数据库: Indonesian Society for Knowledge and Human Development
DOI: 10.18517/ijaseit.9.4.7218
关键词: Bismuth oxide nanoparticlesCytotoxicityReactive oxygen speciesRadiotherapy.
原始语种摘要: Metal-based nanoparticles such as gold, silver, platinum, and bismuth have been widely investigated for radiotherapeutic application. Basic understanding of the cellular interaction of the nanoparticles with the biological materials is crucial to ensure future clinical use. In this study, the cytotoxicity, cellular uptake, and generation of reactive oxygen species (ROS) induced by BiONPs were investigated prior elucidating the feasibility of BiONPs for radiotherapy application using megavoltage photon and electron beams. The BiONPs of diameter sizes 60, 70, 80 and 90 nm at concentrations within a range of 0.5 to 0.00005 mMol/L were tested on MCF-7, MDA-MB-231, and NIH/3T3 cells lines. The cytotoxicity results exhibit minimal cell death constituting less than 20 % of mortality on average....
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  • concentrations 浓聚物
  • oxygen 
  • negligible 可忽略的
  • range 射程
  • enhancement 增强
  • suitable 合适的
  • uptake 上风口
  • biological 生物学的
  • higher 
  • feasibility 可行性