Molecular Differences Between Subtype 3a And 3b Of Hcv By The Interaction Of Ns5b Proteins With Different Competitive Antagonists.
作者: Aparajita Nayak.
刊名: Wyno Academic Journal of Medical Sciences, 2015, Vol.4 (2)
来源数据库: Wyno Academic Journals
关键词: 4AEPGenotypesHCVNS5B ProteinSubtype 3aSubtype 3b.
原始语种摘要: The HCV subtype 3a is unique in producing the symptoms as it causes hepatic steatosis, which is not commonly observed in other genotypes of HCV. The molecular difference between subtypes 3a and 3b remains unexplored. This study tried to explore this difference between these two subtypes. The antagonist bound conformation of NS5B protein of both subtypes 3a and 3b of HCV were modeled using the crystal structure of ‘4aep’ (NS5B, subtype 2a) through homology modeling. Four HCV competitive antagonists [(1) IPC; (2) JPC; (3) 79Z; (4) 26F] were used to find the differences between the subtypes 3a and 3b by the use of docking. Although it showed 88% sequence similarity, however, these were observed to be substantially different, while analyzing the patterns of the intermolecular hydrogen...
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  • observed 观察到的
  • disulfide 二硫化物
  • residues 残余物
  • intermolecular 分子间的
  • conformation 构象
  • binding 装订
  • crucial 有决定性的
  • homology 同源
  • invariant 不变量
  • however 然而