Antidiarrheal, cytotoxic and thrombolytic activities of methanolic extract of Hedychium coccineum leaves
作者: Fahmida ShifahAbu Montakim TareqMohammed Aktar SayeedMohammad Nazmul IslamTalha Bin EmranMd. Ahsan UllahMuhammad Abdul MukitAhmed Ullah
作者单位: 1Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
2 Department of Pharmacy, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh
3 Department of Pharmacy, BGC Trust University Bangladesh, Chandanaish, Chittagong 4381, Bangladesh
刊名: Journal of Advanced Biotechnology and Experimental Therapeutics, 2020, Vol.3 (1), pp.77-83
来源数据库: Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
DOI: 10.5455/jabet.2020.d110
关键词: Hedychium coccineumZingiberaceaeAntidiarrhealThrombolytic
原始语种摘要: The study reports the in vivo antidiarrheal and in vitro cytotoxic and thrombolytic activitiesof methanolic extract of Hedychium coccineum leaves (MEHCL). The antidiarrheal activity was evaluatedby castor oil-induced diarrhea, whereas the intestinal motility by charcoal marker. In addition, brineshrimp lethality bioassay and human blood clot lysis were used to evaluate the cytotoxic andthrombolytic activities, respectively. In antidiarrheal study, castor oil-induced diarrhea andgastrointestinal motility exhibited a significant dose dependent reduction in diarrhea and defecation andan extremely significant (P < 0.0001) inhibition in intestinal motility and peristalsis index by 200 and 400mg/kg of MEHCL. The brine shrimp lethality bioassay revealed a considerable cytotoxic effect of...
全文获取路径: PDF下载  BSMIAB 
分享到:

×
关键词翻译
关键词翻译
  • thrombolytic 溶解血栓的
  • cytotoxic 细胞毒素的
  • antidiarrheal 止泻药
  • diarrhea 腹泻
  • intestinal 肠的
  • significant 有效的
  • bioassay 生物测定
  • extract 提取
  • considerable 相当
  • percentage 百分数