HMG-CoA reductase inhibitor, rosuvastatin averted carbon tetrachloride-induced oxidative stress, inflammation and fibrosis in the liver of rats
作者: Biswajit SikderFarzana AkterAnayt UllaNusrat SubhanIqbal AhmedMd Ashraful Alam
作者单位: 1Department of Pharmaceutical Sciences, North South University, Bangladesh
2 Department of Pharmaceutical Sciences, North South University, Bangladesh
3 Pharmacy Discipline, Khulna University
刊名: Journal of Advanced Biotechnology and Experimental Therapeutics, 2020, Vol.3 (1), pp.01-08
来源数据库: Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
DOI: 10.5455/jabet.2020.d101
关键词: Carbon tetra chlorideInflammationSuperoxide dismutaseRosuvastatinFibrosis
原始语种摘要: The aim of this study was to examine the effect of rosuvastatin in experimentally-inducedhepatic inflammation and fibrosis in rats. Carbon tetra chloride (CCl4) was administered orally to induceliver damage in female Long Evans rats. Rats were treated with CCl4 alone twice a week over twoweeks. Rosuvastatin (10 mg/kg) was also given daily to CCl4 treated rats concurrently by nasogastricgavage. After two weeks, various oxidative stress markers as well as liver markers enzymes wereinvestigated in different animal groups tested in this study. Moreover, histological assessments were alsodone for inflammatory cell infiltration and fibrosis in the liver of all test groups. Plasma aspartateaminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities...
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  • fibrosis 纤维化
  • liver 
  • tetrachloride 四氯化物
  • oxidative 氧化的
  • inflammation 炎症
  • induced 感应的
  • stress 应力
  • superoxide 过氧化物
  • fibrotic 纤维变性的
  • infiltration 渗透