A comparative review on TLQP-21 receptors: rodent versus human
作者: Md Shamim Akhter
作者单位: 1Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh
刊名: Journal of Advanced Biotechnology and Experimental Therapeutics, 2020, Vol.3 (1), pp.09-19
来源数据库: Bangladesh Society for Microbiology, Immunology, and Advanced Biotechnology
DOI: 10.5455/jabet.2020.d102
关键词: VGFTLQP-21HSPA8SHSY-5YReceptor
原始语种摘要: Growing functional information regarding bioactive TLQP-21 has led to the ubiquitous demand for identification of receptors associated to the peptide, which resulted in the first wave of murine TLQP-21 receptors, gC1qR and C3AR1. gC1qR was identified as receptor of TLQP-21 using chemical crosslinking and monomeric avidin column purification following by MS analysis. TLQP-21 responsive CHO-K1 cells were used to search for its receptor, C3AR1. Putative GPCRs, which may partake in regulating intracellular biological functions induced by TLQP-21, were indexed after the CHO-K1 cellular transcriptome was sequenced using unbiased Genome Wide Sequencing. TLQP-21 binding in the cells were found to be reduced by the gene knockdown with the siRNAs targeting C3AR1. C3AR1 antagonist, SB290157 was...
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  • human 人的
  • rodent 啮齿类
  • comparative 比较的
  • murine 鼠灰色
  • affinity 亲和力
  • demonstrable 可证明
  • cells 麻风细胞
  • identification 辨认
  • peptide 
  • binding 装订