SYNERGISTIC EFFECTS OF GSK3 AND p38 MAPK INHIBITORS ON GROWTH OF Plasmodium falciparum EX VIVO
作者: MARHALIM, L EMBI, N.SIDEK, H.M.
刊名: Malaysian Applied Biology, 2014, Vol.43 (1)
来源数据库: Malaysian Society of Applied Biology
关键词: GSK3MAPKinhibitorsPlasmodium falciparummalaria
原始语种摘要: Pharmacological inhibitors of glycogen synthase kinase 3 (GSK3) and p38 mitogen-activated protein kinase (p38 MAPK), two kinases commonly associated with signaling within cells, have been shown to suppress in vivo or ex vivo growth of plasmodial sp. Here we evaluated antiplasmodial activities ex vivo of four inhibitors against GSK3 [lithium chloride (LiCl), kenpaullone, (2’Z, 3’E)-6-bromoindirubin-3’-oxime (BIO) and SB216763]; and two against p38 MAPK (RWJ67657 and SB202190) individually and in combination preparatory to understanding the role of protein kinases in plasmodial development. The order of decreasing growth-suppressing potencies of the GSK3 inhibitors tested against Plasmodium falciparum 3D7 cultured ex vivo in erythrocytes was BIO (IC50=3.13 ?M) > kenpaullone (IC50 = 18.3 ?M)...
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关键词翻译
关键词翻译
  • antiplasmodial 抗疟原虫药
  • against 反对
  • inhibiting 抑制
  • protein 蛋白质
  • suppressing 制止的
  • growth 生长
  • kinase 激酶
  • synergism 协同酌
  • mitogen 促细胞分裂剂
  • combination 聚形