Revisiting the “race for the surface” in a pre-clinical model of implant infection
作者: S M ShielsJ C Wenke
作者单位: 1U.S. Army Institute of Surgical Research, Orthopaedic Trauma Department, Fort Sam Houston, TX,
刊名: Eur Cell Mater, 2020, Vol.39 , pp.77-95
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v039a05
原始语种摘要: Orthopaedic implant use increases infection risk. Implant infection risk can be explained by the “race for the surface” concept, where there is competition between host-cell integration and bacterial colonisation. Although generally accepted, the temporal dynamics have not been elucidated in vivo. Using a bilateral intramedullary rat model, Staphylococcus aureus was injected into the tail vein either immediately after or 1, 3 and 7 d following implant placement. This allowed assessment of the temporal interplay between bacterial colonisation and host-cell adhesion by uncoupling implant placement and bacterial challenge. 2 weeks following inoculation, animals were anaesthetised, euthanised and implants and tissues harvested for bacterial enumeration. To assess host participation in implant...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • implant 离子注入
  • infection 感染
  • bacterial 细菌的
  • cells 麻风细胞
  • immature 未熟的
  • orthopaedic 矫形术的
  • guidance 制导
  • temporal 现世的
  • antimicrobial 杀菌剂
  • challenge 询问