Intervertebral disc and endplate cell characterisation highlights annulus fibrosus cells as the most promising for tissue-specific disc degeneration therapy
作者: P De LucaL de GirolamoE RagniG LuganoD Coviello
作者单位: 1IRCCS Istituto Ortopedico Galeazzi, Orthopaedic Biotechnology Lab, Milan,
刊名: Eur Cell Mater, 2020, Vol.39 , pp.156-170
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v039a10
原始语种摘要: Degenerative processes of the intervertebral disc (IVD) and cartilaginous endplate lead to chronic spine pathologies. Several studies speculated on the intrinsic regenerative capacity of degenerated IVD related to the presence of local mesenchymal progenitors. However, a complete characterisation of the resident IVD cell populations, particularly that isolated from the endplate, is lacking. The purpose of the present study was to characterise the gene expression profiles of human nucleus pulposus (NPCs), annulus fibrosus (AFCs) and endplate (EPCs) cells, setting the basis for future studies aimed at identifying the most promising cells for regenerative purposes.Cells isolated from NP, AF and EP were analysed after in vitro expansion for their stemness ability, immunophenotype and gene...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • endplate 端板
  • cells 麻风细胞
  • annulus 体环
  • mesenchymal 间叶细胞的
  • adipogenic 生脂的
  • tissue 组织
  • promising 前提
  • osteogenic 成骨的
  • specific 
  • regenerative 再生放大