Initiation and emerging complexity of the collagen network during prenatal skeletal development
作者: S Ahmed
作者单位: 1Department of Bioengineering, Imperial College London, London, United
刊名: Eur Cell Mater, 2020, Vol.39 , pp.136-155
来源数据库: European Cells and Materials (eCM)
DOI: 10.22203/eCM.v039a09
原始语种摘要: The establishment of a complex collagen network is critical for the architecture and mechanical properties of cartilage and bone. However, when and how the key collagens in cartilage and bone develop has not been characterised in detail. The study provides a detailed qualitative characterisation of the spatial localisations of collagens I-III, V-VI and IX-XI in the mouse and their regional architecture variation over three developmentally significant time points: when the rudiment starts to form at E13.5 [Theiler stage (TS) 22], when mineralisation is present at E16.5 (TS25) and during the latest prenatal stage at E18.5 (TS27). Dynamic changes in collagen distribution between stages with the progression of the growth plate and mineralisation (particularly collagens I, II, V, X and XI) and...
全文获取路径: European Cells and Materials (eCM) 
影响因子:4.558 (2012)

  • development 开发
  • collagen 胶骨硬蛋白质
  • during 在的期间
  • prenatal 产前的
  • organisation 组织
  • three 
  • regional 地方的
  • rudiment 退化瀑
  • emergence 上升
  • establishment 确立