THE CONSIDERATIONS AND THE REQUIRED STEPS FOR PRODUCTION OF THE PLANT SEEDS VACCINES WITH FOCUS ON THE ORAL DELIVERY
3注意事项及生产所需步骤以口服给药为重点的植物种子疫苗
作者: MAHDI YONESIALIREZA REZAZADEHMELINTIANA MARIA MOUSAI
作者单位: 1Centro de Tecnología Biomédica (CTB), Universidad Politécnica de Madrid, Madrid, Spain.
2Faculty of Agricultural Sciences, Shahed University, Tehran, Iran.
3School of Life Science, Huxley Building, Keele University, Newcastle-under-Lyme, UK.
刊名: PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 2020, pp.36-51
来源数据库: International Knowledge Press
关键词: Recombinant vaccineOral delivery systemTransgenic seeds.
原始语种摘要: The recombinant vaccinal proteins can provide a solution for prevention of the contagious diseases, especially in deprived countries. While using eukaryotic platforms such as E. coli lack the post-translational modifications for expression of the proteins and using mammalian cells and plant cells encounter a labor-intensive and continuous process of cell culture and the final product requires special transportation logistics, the plant seeds can provide a good solution for expression of the vaccinal proteins as an oral vaccine. Seeds contain a low amount of water content and can show a considerable bioencapsulation to protect the recombinant products from environmental degradation. However, for the expression of a recombinant protein, there are steps and considerations that should be...
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关键词翻译
关键词翻译
  • proteins 蛋白质
  • expression 表示
  • recombinant 重组体
  • eukaryotic 真核的
  • vaccinal 牛痘的
  • translational 平移的
  • platform 台地
  • targeting 导向目标
  • protect 庇护
  • vaccine 菌苗