PHENOTYPIC AND GENOTYPIC CHARACTERISATION OF CARBAPENEM RESISTANT Klebsiella pneumoniae CLINICAL ISOLATES FROM A TERTIARY CARE HOSPITAL
A三级医院耐碳青霉烯类肺炎克雷伯菌临床分离株表型及GENOTYPIC特征
作者: B. ADITI PRIYADARSHINIKRISHNAN MAHALAKSHMI
作者单位: 1Department of Microbiology, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-73, India.
2Department of Microbiology, Sree Balaji Dental College and Hospital, Chennai, India.
刊名: PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, 2020, pp.27-35
来源数据库: International Knowledge Press
关键词: Antimicrobial resistanceCarbapenemasesCarbapenem resistanceMulti drug resistanceKlebsiella pneumoniae.
原始语种摘要: Background: The evolution of multidrug resistant Klebsiella pneumoniae is a global threat in treating nosocomial infections. Carbapenem resistant Klebsiella pneumoniae (CRKP) are a group of emerging highly drug-resistant Gram-negative bacilli that produces class A, B and D beta lactamases which help in hydrolyzing carbapenems thereby warranting alternate drug therapy. This study was aimed to determine the prevalence of CRKP phenotypically and genotypically. Methods: The identification and antibiotic susceptibility testing of K. pneumoniae isolates were performed by vitek 2 systems version 7.0 as per CLSI guidelines. Phenotypic detection of carbapenemase was performed by combined-disc test using meropenem alone and with both phenyl boronic acid and EDTA. Genotypic detection was performed...
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关键词翻译
关键词翻译
  • carbapenem 氨基甲酰
  • isolates 单离体
  • antibiotic 抗生素
  • resistant 耐久的
  • hydrolyzing 水解的
  • nosocomial 医院的
  • cephalosporins 头孢菌素类
  • bacilli 杆状菌
  • colistin 粘菌素
  • susceptibility 磁化率