The function of microparticles and the research progress of diabetes and microparticles
微粒的功能及其与糖尿病的研究进展
作者: Min-dan XuKe-qin Zhang
作者单位: 1Dept. of Emergency, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
2Dept. of Endocrinology and Metabolism, Tongji Hospital, Tongji University School of Medicine, Shanghai, China
刊名: Global Journal of Endocrinology and Metabolism Studies, 2017, Vol.3 (1)
中文刊名: 国际内分泌与代谢研究, 2017, Vol.3 (1)
来源数据库: New Century Science Press LLC
DOI: 10.14725/gjems.v3n1.a1332
关键词: MicroparticlesTissue factorDiabetesHypercoagulable
中文关键词: 微粒: 织因子: 糖尿病: 高凝状态
中文摘要: 微粒是由细胞受物理或化学刺激或者凋亡时产生的带细胞膜的囊泡。其大小在100~1000nm之间,表面的膜细胞骨架上含有磷脂酰丝氨酸及多种细胞分子,其包膜内无核,含有细胞分子、RNA、DNA等。在机体中起到信号传递的作用。近年来发现,微粒参与多种疾病的病理生理过程,如糖尿病、冠心病、深静脉血栓、肿瘤等,在以上疾病过程中,微粒主要有促炎、促凝等作用。糖尿病患者存在明显的高凝状态,糖尿病患者合并心血管疾病死亡率近年来有增高趋势,血栓事件较非糖尿病患者增加。糖尿病患者血浆中内皮源性微粒数目增多,组织因子阳性微粒比例升高,微粒促凝活性升高。微粒的改变是否参与糖尿病患者的高凝状态的发生值得研究。
原始语种摘要: MPs are vesicles released by cells when stimulated by physical (e.g. shear force) or chemical (e.g. agonists) factors, as well as cells undergoing apoptosis or exposed to inflammatory conditions . MPs are 100 ~ 1000 nm in diameter, have membrane cytoskeletons, express phosphatidylserine (PS) on the surface, and lack of nuclei. Surface molecules, enzymes, RNA and DNA are conveyed via MPs from origin cells to target cells. As mediators of information transfer, MPs have been proposed to impose pro-inflammatory and pro-coagulant effects in many disease states, such as cancer, venous thromboembolism, arteriosclerosis, and diabetes mellitus. The hypercoagulable state associated with diabetes is well recognized. More T2DM patients have died from thrombotic diseases. The endothelium-derived MPs...
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关键词翻译
关键词翻译
  • diabetes 糖尿病
  • state 状态
  • elevated 高的
  • cells 麻风细胞
  • diabetic 糖尿病患者
  • coagulant 凝结剂
  • stimulated 受激
  • inflammatory 激怒的
  • thrombotic 血栓形成的
  • research